Monday, October 6, 2014

10 Months of Resveratrol Improves Alzheimer's in the Lab

Resveratrol is a common supplement extracted from grapes or red wine. In a laboratory study of familial Alzheimer's, resveratrol had a significant impact in improving memory as well as physically halting the disease. Find out how resveratrol did it and the scope of its impact.

A study coordinated by the University of Barcelona (UB) has described a mechanism that plays a key role in the evolution of Alzheimer's disease.

Continued below photos...
This is the first study that describes sirtuin pathway in a murine model.
Credit: Image courtesy of Universidad de Barcelona

According to the paper published in the Journal of Alzheimer's Disease, the activation of the protein Sirtuin 1 in a murine model with familial Alzheimer's disease has neuroprotective effects. The study, based on the PhD thesis developed by the researcher David Porquet (UB), first describes Sirtuin 1 pathway in this murine model. Mercè Pallàs, from the Department of Pharmacology and Therapeutic Chemistry at the Faculty of Pharmacy of UB, coordinates the study. The Bellvitge Biomedical Research Institute (IDIBELL) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) also collaborate in the study.


A group of mice was fed with resveratrol, a natural polyphenolic compound found in grapes and red wine. Mice were modified to develop familial Alzheimer's disease, an inherited neurodegenerative disorder that represents 5% of dementia cases and normally has an early onset. Resveratrol dose was equivalent to dietary supplementation and administered for 10 months. Then, its effects on cognitive function and neuronal tissues were compared with a control group that did not receive any supplementation. "Results showed that resveratrol ameliorated short-term memory and stopped the accumulation of senile plaques and the development of tau protein, the two most important characteristics of the disease," explains Mercè Pallàs, researcher from the Research Group on Aging and Neurodegeneration of UB and the Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED).

Researchers studied which mechanisms are activated in this process. Particularly, they focused their attention on Sirtuin 1, a protein involved in aging. "We used resveratrol because it is thought that one part of its beneficial effects is due to an increase in sirtuin activity." "Although sirtuin proteic levels decreased -- she adds -- , its activity was increased." Surprisingly, the study showed an increase in other intracellular mechanisms. Therefore, "resveratrol's beneficial action increases these other mechanisms and mitochondrial function," concludes the researcher.

According to Pallàs, "sirtuin pathway may be a good Alzheimer's disease treatment target. The study proves that if this pathway is regulated, in this case with resveratrol, the evolution of Alzheimer's disease in this murine model of familial Alzheimer's disease is modified."

Sirtuin and aging

A previous study developed by the research group had already proved the important role that Sirtuin 1 plays in aging. "We administered the same type of resveratrol treatment to mice with accelerated senescence -- modified to get older quicker -- and we observed an increase of their life expectancy which was related to sirtuin activation," points out Pallàs.

Further studies need to be conducted to elucidate whether or not resveratrol is also able to protect against mitochondrial dysfunction. "If we corroborate the key role played by mytochondria-sirtuin interaction, the activation of sirtuin with resveratrol might have protective effects on high-fat diet-fed mice, which are supposed to suffer mitochondrial dysfunction," says the researcher.


Journal Reference:
  1. David Porquet, Christian Griñán-Ferré, Isidre Ferrer, Antoni Camins, Coral Sanfeliu, Jaume del Valle, Mercé Pallás. Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's DiseaseJournal of Alzheimer's, September 2014 DOI: 10.3233/JAD-140444

1 comment:

  1. Hello, here we go again. Curing mice of their Alzheimer's when in fact we don't know if they really have Alzheimer's. We don't know it because no one know what cause Alzheimer's disease, not even nude mice.

    The complicated and as yet not fully known or understood human brain get reduced to a "how long did it take the mouse to find the cheese, or avoid the shock standard. If the mouse "forgot what s/he previously learned, and that mouse had Mouse Alzheimer's disease", and therefore took longer to find the cheese or got shocked than did the mouse who did not have Mouse Alzheimer's Disease - and - the chemical we introduced into the mouses brain was the only difference between the two sets of mice abilities to remember, than BINGO we have found a way to cure Alzheimer's Disease.

    Lots of jumps in logic, evidence, scientific consesus in that process. Mostly these subtles in jumping to conclusions are jumped over, and we just ignore the facts and jump to the conclusion we claim the mice are telling us.

    Perhaps we should listen less to mice and more to folks living with the symptoms of dementia. Perhaps we should focus on understanding their needs and wants and let the mice live in their own mouse world. Richard


Comment here:










Diet & Nutrition

  1. Foods
  2. Coconut Oil
  3. Dairy
  4. Diets
  5. Fruit & Vegetables
  6. Herbs & Spices
  7. Medical Food (FDA)
  8. Mediterranean
  9. Recipes
  10. Risky Foods
  11. Tips
  12. Vitamins &



All About